反应详情

温度

45 °C

Into a round bottom flask, 6-Bromo-2-thioxo-2,3-dihydro-1H-pyrrolo[2,1-f][1,2,4]triazin-4-one (11.20 g, 0.04551 mol), Tetrahydrofuran (200 mL) and Methyl iodide (6.517 mL, 0.1047 mol) were added, respectively. The reaction was stirred at 45° C. for one hour. The solid was filtered. The solvent was removed under vacuum to give a solid. The combined solid was partitioned with water (500 mL) and saturated NaHCO3 (500 mL). The mixture was stirred for 30 minutes. The solid was filtered and washed with water to give 6-Bromo-2-methylsulfanyl-3H-pyrrolo[2,1-f][1,2,4]triazin-4-one as a white solid (5.80, 49%).

1. filtrationThe solid was filtered
2. customThe solvent was removed under vacuum
3. customto give a solid
4. customThe combined solid was partitioned with water (500 mL) and saturated NaHCO3 (500 mL)
5. stirringThe mixture was stirred for 30 minutes
6. filtrationThe solid was filtered
7. washwashed with water