HCID 66711800, compound → HCID 66712093, compound

HRID 1262285Notes

Reaction equation

HRID 1262285 reaction equation
C(OC(N1CCCCC1C1N2C(C=NC(NC3C=CC(N4CCOCC4)=CC=3)=N2)=CC=1)=O)(C)(C)C.C(OC([N:43]1[CH2:48][CH2:47][N:46]([C:49]2[CH:54]=[CH:53][CH:52]=[C:51]([C:55]3[N:63]4[C:58]([CH:59]=[N:60][C:61]([NH:64][C:65]5[CH:70]=[CH:69][C:68]([N:71]6[CH2:76][CH2:75][N:74]([CH3:77])[CH2:73][CH2:72]6)=[CH:67][CH:66]=5)=[N:62]4)=[CH:57][CH:56]=3)[CH:50]=2)[CH2:45][CH2:44]1)=O)(C)(C)C>>[CH3:77][N:74]1[CH2:75][CH2:76][N:71]([C:68]2[CH:69]=[CH:70][C:65]([NH:64][C:61]3[N:60]=[CH:59][C:58]4=[CH:57][CH:56]=[C:55]([C:51]5[CH:52]=[CH:53][CH:54]=[C:49]([N:46]6[CH2:45][CH2:44][NH:43][CH2:48][CH2:47]6)[CH:50]=5)[N:63]4[N:62]=3)=[CH:66][CH:67]=2)[CH2:72][CH2:73]1

Participants

3

Reactant 2

HCID 66711800HCID 66711800, compoundHCID 66712575HCID 66712575, compound

Product 1

HCID 66712093HCID 66712093, compound

Procedure

The titled compound was prepared in an analogous fashion to Example 1129 replacing [2-(4-Morpholin-4-yl-phenylamino)-pyrrolo[2,1-f][1,2,4]triazin-7-yl]-piperidine-1-carboxylic acid tert-butyl ester with 4-(3-{2-[4-(4-Methyl-piperazin-1-yl)-phenylamino]-pyrrolo[2,1-f][1,2,4]triazin-7-yl}-phenyl)-piperazine-1-carboxylic acid tert-butyl ester to give a yellow solid (180 mg, 76%). LCMS (E/I+) 469.21 (M+H). NMR 1H (DMSO-d6)-975 (s, 1H), 9.31 (s, 1H), 8.94 (s, 1H), 8.61 (bs, 1H), 7.89 (q, 1H, J=7.30 Hz), 7.68 (d, 2H, J=7.76 Hz), 7.56 (s, 1H), 7.45 (t, 1H, J=7.76 Hz), 7.18 (d, 1H, J=4.57 Hz), 7.04 (d, 1H, J=8.22 Hz), 6.89-6.99 (m, 3H), 3.77 (d, 2H, J=13.72 Hz), 3.54 (d, 2H, J=11.76 Hz), 3.41 (bs, 4H), 3.24 (bs, 4H), 3.10-3.21 (m, 2H), 2.82-2.98 (m, 5H).

Sources & evidence

ORD record
ord-dcfc2833bcf04fc9b3cc8005ad37c33d
Source dataset
uspto-grants-2013_06
Patent number
US08471005B2

Reaction notes

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