HCID 66711800, compound → HCID 66712093, compound

Participants

Reaction Steps

The titled compound was prepared in an analogous fashion to Example 1129 replacing [2-(4-Morpholin-4-yl-phenylamino)-pyrrolo[2,1-f][1,2,4]triazin-7-yl]-piperidine-1-carboxylic acid tert-butyl ester with 4-(3-{2-[4-(4-Methyl-piperazin-1-yl)-phenylamino]-pyrrolo[2,1-f][1,2,4]triazin-7-yl}-phenyl)-piperazine-1-carboxylic acid tert-butyl ester to give a yellow solid (180 mg, 76%). LCMS (E/I+) 469.21 (M+H). NMR 1H (DMSO-d6)-975 (s, 1H), 9.31 (s, 1H), 8.94 (s, 1H), 8.61 (bs, 1H), 7.89 (q, 1H, J=7.30 Hz), 7.68 (d, 2H, J=7.76 Hz), 7.56 (s, 1H), 7.45 (t, 1H, J=7.76 Hz), 7.18 (d, 1H, J=4.57 Hz), 7.04 (d, 1H, J=8.22 Hz), 6.89-6.99 (m, 3H), 3.77 (d, 2H, J=13.72 Hz), 3.54 (d, 2H, J=11.76 Hz), 3.41 (bs, 4H), 3.24 (bs, 4H), 3.10-3.21 (m, 2H), 2.82-2.98 (m, 5H).

Provenance & Evidence