反应详情

2.5 g of sodium hydride paste (60% in mineral oil) was added in portions to a stirred solution of 9.9 g of 2,5-difluoronitrobenzene and 12.7 g of 1E in 200 ml of dimethyl sulfoxide. The resulting mixture was held at 160°-170° C. for 24 hours, then was cooled, diluted with 1000 ml of water and extracted with ether. The extract was chromatographed on silica gel to give ethyl 2-(4-(4-fluoro-2-nitrophenyl-amino)phenoxy)propionate (7A) as a viscous oil.

1. temperaturewas cooled
2. extractionextracted with ether
3. customThe extract was chromatographed on silica gel