HCID 20456652, compound → HCID 15589122, compound

HRID 1262461Notes

Reaction equation

HRID 1262461 reaction equation
[N:1]([O-])=O.[Na+].[NH2:5][C:6]1[CH:11]=[C:10]([F:12])[CH:9]=[CH:8][C:7]=1[NH:13][C:14]1[CH:27]=[CH:26][C:17]([O:18][CH:19]([CH3:25])[C:20]([O:22]CC)=[O:21])=[CH:16][CH:15]=1>O.Cl>[F:12][C:10]1[CH:9]=[CH:8][C:7]2[N:13]([C:14]3[CH:27]=[CH:26][C:17]([O:18][CH:19]([CH3:25])[C:20]([OH:22])=[O:21])=[CH:16][CH:15]=3)[N:1]=[N:5][C:6]=2[CH:11]=1

Participants

5

Reactant 2

HCID 20456652HCID 20456652, compoundHCID 23668193Sodium Nitrite

Product 1

HCID 15589122HCID 15589122, compound

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 962WaterSolvent

Procedure

A solution of 2.1 of sodium nitrite in 25 ml of water was added drop-by-drop to a stirred solution of 6.7 g of 7B in 150 ml of 12% hydrochloric acid at 2° C. The resulting mixture was stirred at room temperature for 12 hours, then was filtered. Recrystallization of the filter cake from ether/hexane gave 7, as a solid, m.p.: 164°-166° C.

Workup

  1. filtrationwas filtered
  2. customRecrystallization of the filter cake from ether/hexane
  3. customgave 7

Sources & evidence

ORD record
ord-b9c9ed8b773a433aa71b6171ef328e18
Source dataset
uspto-grants-1984_06
Patent number
US04452626

Reaction notes

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