Potassium Hydroxide → MLS002706610

HRID 1262512Notes

Reaction equation

HRID 1262512 reaction equation
C([O:3][C:4]([C:6]1[C:10]([C:11]([O:13][CH2:14][CH3:15])=[O:12])=[CH:9][O:8][CH:7]=1)=[O:5])C.[OH-].[K+]>C(O)C>[CH2:14]([O:13][C:11]([C:10]1[C:6]([C:4]([OH:5])=[O:3])=[CH:7][O:8][CH:9]=1)=[O:12])[CH3:15]

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 353993,4-Furandicarboxylic acid, diethyl ester

Product 1

HCID 271570MLS002706610

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 235 gm of furan-3,4-dicarboxylic acid diethyl ester and 62.1 gm of potassium hydroxide in 800 ml of 60% ethanol was stirred for 2 hours at room temperature, and then the solvent was distilled off in vacuo. The residue was acidified by carefully adding an aqueous KHSO4 solution dropwise thereto, while stirring, and the monoester was extracted with methylene chloride and crystallized from ethyl acetate/petroleum ether.

Workup

  1. distillationthe solvent was distilled off in vacuo
  2. additionby carefully adding an aqueous KHSO4 solution dropwise
  3. extractionthe monoester was extracted with methylene chloride
  4. customcrystallized from ethyl acetate/petroleum ether

Sources & evidence

ORD record
ord-e5ac6c5600514fe0afecdff490d05b55
Source dataset
uspto-grants-1984_06
Patent number
US04452789

Reaction notes

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