Hydrochloric Acid → 1-[4-[4-(1,2-Benzisothiazol-3-yl)-1-piperazinyl]butyl]-4-methyl-4-propyl-2,6-piperidinedione

HRID 1262547Notes

Reaction equation

HRID 1262547 reaction equation
Cl.Br[CH2:3][CH2:4][CH2:5][CH2:6][N:7]1[C:12](=[O:13])[CH2:11][C:10]([CH3:17])([CH2:14][CH2:15][CH3:16])[CH2:9][C:8]1=[O:18].[N:19]1([C:25]2[C:29]3[CH:30]=[CH:31][CH:32]=[CH:33][C:28]=3[S:27][N:26]=2)[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]1>>[S:27]1[C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][C:29]=2[C:25]([N:19]2[CH2:20][CH2:21][N:22]([CH2:3][CH2:4][CH2:5][CH2:6][N:7]3[C:12](=[O:13])[CH2:11][C:10]([CH3:17])([CH2:14][CH2:15][CH3:16])[CH2:9][C:8]3=[O:18])[CH2:23][CH2:24]2)=[N:26]1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 27721443-(1-Piperazinyl)-1,2-benzisothiazoleHCID 13232512N-(4-Bromobutyl)-3-methyl-3-n-propylglutarimide

Product 1

HCID 132324911-[4-[4-(1,2-Benzisothiazol-3-yl)-1-piperazinyl]butyl]-4-methyl-4-propyl-2,6-piperidinedione

Procedure

Title product hydrochloride--Reaction of N-(4-bromobutyl)-3-methyl-3-n-propylglutarimide with 3-(1-piperazinyl)-1,2-benzisothiazole and conversion of the free base to the hydrochloride salt according to the procedure of Example 3 affords 1-[4-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]butyl]-4-methyl-4-propyl-2,6-piperidinedione hydrochloride, m.p. 163°-165° C.

Sources & evidence

ORD record
ord-dda2caae99184f5b87b281f7e483a088
Source dataset
uspto-grants-1984_06
Patent number
US04452799

Reaction notes

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