3-(1-Piperazinyl)-1,2-benzisothiazole → HCID 13232494, compound

HRID 1262549Notes

Reaction equation

HRID 1262549 reaction equation
O.Cl.BrCCCC[CH:8]1[C:14]([CH2:17][CH3:18])([CH2:15][CH3:16])[CH2:13][C:12](=[O:19])[NH:11][C:9]1=[O:10].[N:20]1([C:26]2[C:30]3[CH:31]=[CH:32][CH:33]=[CH:34][C:29]=3[S:28][N:27]=2)[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]1>C(O)(C)C>[S:28]1[C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][C:30]=2[C:26]([N:20]2[CH2:25][CH2:24][N:23]([CH2:9][CH2:8][CH2:14][CH2:13][N:11]3[C:9](=[O:10])[CH2:8][C:14]([CH2:15][CH3:16])([CH2:17][CH3:18])[CH2:13][C:12]3=[O:19])[CH2:22][CH2:21]2)=[N:27]1

Participants

5

Reactant 3

HCID 27721443-(1-Piperazinyl)-1,2-benzisothiazoleHCID 21885828Hydrate;hydrochlorideHCID 86739441HCID 86739441, compound

Product 1

HCID 13232494HCID 13232494, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

Title product hydrochloride hydrate--Reaction of N-(4-bromobutyl-3,3-diethylglutarimide and 3-(1-piperazinyl)-1,2-benzisothiazole and conversion of the free base to the hydrochloride salt in isopropanol according to the procedure of Example 3 affords 1-[4-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]butyl]-4,4-diethyl-2,6-piperidinedione hydrochloride hydrate, m.p. 179°-183° C., from acetonitrile.

Sources & evidence

ORD record
ord-7d1c8446cdde4e4996c478529ab8a31e
Source dataset
uspto-grants-1984_06
Patent number
US04452799

Reaction notes

Loading…