Methanesulfonic Acid → 4,4'-Dihydroxybenzophenone

HRID 1262741Notes

Reaction equation

HRID 1262741 reaction equation
C1(O[C:8](=[O:16])[C:9]2[CH:14]=[CH:13][C:12]([OH:15])=[CH:11][CH:10]=2)C=CC=CC=1.CS(O)(=O)=O>O>[OH:15][C:12]1[CH:13]=[CH:14][C:9]([C:8]([C:9]2[CH:10]=[CH:11][C:12]([OH:15])=[CH:13][CH:14]=2)=[O:16])=[CH:10][CH:11]=1

Participants

4

Reactant 2

HCID 6395Methanesulfonic AcidHCID 87250Phenylparaben

Product 1

HCID 691504,4'-Dihydroxybenzophenone

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Phenyl-4-hydroxybenzoate (5.0 g; 0.02 mole) was heated with 98% methane sulphonic acid (10 ml; 15.1 g; 0.16 mole) at 80° C. for 2 hours. The solution was poured into water and the solid product washed with water and dried at 110° C. in a vacuum oven to yield 4,4'-dihydroxy-benzophenone (infra-red spectrum indentical with that of an authentic sample); the yield was 3.4 g (68%).

Workup

  1. washthe solid product washed with water
  2. customdried at 110° C. in a vacuum oven

Sources & evidence

ORD record
ord-415c10ceba2e4860a0ce239f8ebea06a
Source dataset
uspto-grants-1984_06
Patent number
US04453010

Reaction notes

Loading…