Hydrochloric Acid → HCID 178429635, compound

Participants

Reaction Steps

To a suspension of 7-[2-(2-aminothiazol-4-yl)-2-carboxymethoxyiminoacetamido]-3-methylthio-3-cephem-4-carboxylic acid (syn isomer) (10 g) in water (80 ml) was added dropwise conc. hydrochloric acid (10 ml) at room temperature under stirring and the mixture was stirred at the same temperature for one hour. The precipitates were filtered and washed with cold water and dried to give 7-[2-(2-aminothiazol-4-yl)-2-carboxymethoxyiminoacetamido]-3-methylthio-3-cephem-4-carboxylic acid hydrochloride (syn isomer) (9.5 g).

Provenance & Evidence