Hydrochloric Acid → HCID 178429635, compound

HRID 1262775Notes

Reaction equation

HRID 1262775 reaction equation
[NH2:1][C:2]1[S:3][CH:4]=[C:5]([C:7](=[N:24][O:25][CH2:26][C:27]([OH:29])=[O:28])[C:8]([NH:10][CH:11]2[C:22](=[O:23])[N:13]3[C:14]([C:19]([OH:21])=[S:20])=[C:15]([CH3:18])[CH2:16][S:17][C@H:12]23)=[O:9])[N:6]=1.[ClH:30]>O>[ClH:30].[NH2:1][C:2]1[S:3][CH:4]=[C:5]([C:7](=[N:24][O:25][CH2:26][C:27]([OH:29])=[O:28])[C:8]([NH:10][CH:11]2[C:22](=[O:23])[N:13]3[C:14]([C:19]([OH:21])=[S:20])=[C:15]([CH3:18])[CH2:16][S:17][C@H:12]23)=[O:9])[N:6]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 178429634HCID 178429634, compound

Product 1

HCID 178429635HCID 178429635, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To a suspension of 7-[2-(2-aminothiazol-4-yl)-2-carboxymethoxyiminoacetamido]-3-methylthio-3-cephem-4-carboxylic acid (syn isomer) (10 g) in water (80 ml) was added dropwise conc. hydrochloric acid (10 ml) at room temperature under stirring and the mixture was stirred at the same temperature for one hour. The precipitates were filtered and washed with cold water and dried to give 7-[2-(2-aminothiazol-4-yl)-2-carboxymethoxyiminoacetamido]-3-methylthio-3-cephem-4-carboxylic acid hydrochloride (syn isomer) (9.5 g).

Workup

  1. stirringthe mixture was stirred at the same temperature for one hour
  2. filtrationThe precipitates were filtered
  3. washwashed with cold water
  4. customdried

Sources & evidence

ORD record
ord-483cdfcc42cc45f381d4d1b84e042aa6
Source dataset
uspto-grants-1984_06
Patent number
US04452851

Reaction notes

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