Benzylamine → Diethyl 3-benzylamino-2-pentenedioate

HRID 1262955노트

반응식

HRID 1262955 반응식
[CH2:1]([NH2:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:9][CH2:10][O:11][C:12]([CH2:14][C:15]([CH2:17][C:18]([O:20][CH2:21][CH3:22])=[O:19])=O)=[O:13]>C1(C)C=CC=CC=1>[CH2:10]([O:11][C:12](=[O:13])[CH:14]=[C:15]([NH:8][CH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1)[CH2:17][C:18]([O:20][CH2:21][CH3:22])=[O:19])[CH3:9]

참가 물질

4

반응물 2

HCID 7504BenzylamineHCID 66045Diethyl acetonedicarboxylate

생성물 1

HCID 70353029Diethyl 3-benzylamino-2-pentenedioate

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

Benzylamine (89.1 g, 0.83 moles) is added over 10 minutes to a suspension of 5A powdered molecular sieves (270 g) and diethyl 1,3-acetonedicarboxylate (160 g) (0.79 moles) in 350 ml toluene (external cooling applied to control exotherm). The suspension is stirred at room temperature for 14-17 hours and then filtered to provide 2. The filter cake is washed with three portions of toluene. The combined filtrates may be used as in the subsequent ketene reaction.

후처리

  1. filtrationfiltered
  2. customto provide 2
  3. washThe filter cake is washed with three portions of toluene
  4. customThe combined filtrates may be used as in the subsequent ketene reaction

출처 및 근거

ORD 기록
ord-3d56d55105f14d65bb30d9b980cfad2f
출처 데이터셋
uspto-grants-1984_06
특허 번호
US04454332

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