Phenylacetic Acid → Phenylacetyl chloride

HRID 1263045Notes

Reaction equation

HRID 1263045 reaction equation
S(Cl)([Cl:3])=O.[C:5]1([CH2:11][C:12]([OH:14])=O)[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1>>[C:5]1([CH2:11][C:12]([Cl:3])=[O:14])[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1

Participants

3

Reactant 2

HCID 999Phenylacetic AcidHCID 24386Thionyl Chloride

Product 1

HCID 7679Phenylacetyl chloride

Procedure

An amount described in Table 1 of thionyl chloride was added to an amount described in Table 1 of a derivative of phenylacetic acid and heated under reflux for one to four hours. Excess of thionyl chloride was distilled out under reduced pressure to obtain a derivative of phenylacetyl chloride.

Workup

  1. additionwas added to an amount
  2. temperatureheated
  3. temperatureunder reflux for one to four hours
  4. distillationExcess of thionyl chloride was distilled out under reduced pressure

Sources & evidence

ORD record
ord-ea6f48eec5564926b954658a692bd440
Source dataset
uspto-grants-1984_06
Patent number
US04455164

Reaction notes

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