3,3-Dimethylbutanoyl chloride → 8-Bromo-1-(2,2-dimethylpropyl)-6-phenyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine

HRID 1263058Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1263058
[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[N:11]=[C:10]([NH:12][NH2:13])[CH2:9][N:8]=[C:7]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[C:6]=2[CH:20]=1.[C:21]([CH2:25][C:26](Cl)=O)([CH3:24])([CH3:23])[CH3:22]>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[N:11]3[C:26]([CH2:25][C:21]([CH3:24])([CH3:23])[CH3:22])=[N:13][N:12]=[C:10]3[CH2:9][N:8]=[C:7]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[C:6]=2[CH:20]=1

Komponenten

3

Edukt 2

HCID 815143,3-Dimethylbutanoyl chlorideHCID 125708627-bromo-2-hydrazino-5-phenyl-3H-1,4-benzodiazepine

Produkt 1

HCID 133433468-Bromo-1-(2,2-dimethylpropyl)-6-phenyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine

Versuchsvorschrift

Following the procedure of Example 5, 2.0 g of 7-bromo-2-hydrazino-5-phenyl-3H-1,4-benzodiazepine is reacted with 1.01 ml of tert-butyl acetylchloride to yield 1.17 g of title product with melting point 229.5°-232° C. and 0.30 g of title product with melting point 205°-219° C.

Quellen und Nachweise

ORD-Eintrag
ord-c75af68d90a04b4d869e5131bcde41fa
Quelldatensatz
uspto-grants-1984_06
Patentnummer
US04455307

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