Water → 3-Chloro-2-methyl-6-nitrobenzonitrile

HRID 1263062노트

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HRID 1263062 반응식
Cl[C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][CH:5]=[C:4]([Cl:11])[C:3]=1[CH3:12].[Cu][C:14]#[N:15].O>CS(C)=O>[CH3:12][C:3]1[C:4]([Cl:11])=[CH:5][CH:6]=[C:7]([N+:8]([O-:10])=[O:9])[C:2]=1[C:14]#[N:15]

참가 물질

5

반응물 3

HCID 962WaterHCID 971552,6-Dichloro-3-nitrotolueneHCID 178418546HCID 178418546, 화합물

생성물 1

HCID 220089613-Chloro-2-methyl-6-nitrobenzonitrile수율 60%

시약·촉매·용매 1

HCID 679Dimethyl Sulfoxide용매

실험 절차

1 mol of 2,6-dichloro-3-nitrotoluene in 1 l of dimethyl sulfoxide was stirred at 150° for 5 hours with 1 mol of copper (I) cyanide. The mixture was then cooled, poured into water and extracted with ethyl acetate. The organic phase was evaporated and the residue was purified by chromatography on silica gel. There was obtained 2-methyl-3-chloro-6-nitrobenzonitrile (yield 60%), m.p. 97°-98°.

후처리

  1. temperatureThe mixture was then cooled
  2. extractionextracted with ethyl acetate
  3. customThe organic phase was evaporated
  4. customthe residue was purified by chromatography on silica gel

출처 및 근거

ORD 기록
ord-d9c9e068baac4471ade2bf0d597938b4
출처 데이터셋
uspto-grants-1984_06
특허 번호
US04455311

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