L-Lysine → HCID 11445447, compound

HRID 1263072Notes

Reaction equation

[NH2:1][C@H:2]([C:8]([OH:10])=[O:9])[CH2:3][CH2:4][CH2:5][CH2:6][NH2:7].[NH2:11][C@H:12]([C:21]([OH:23])=O)[CH2:13][C:14]1[CH:19]=[CH:18][C:17]([OH:20])=[CH:16][CH:15]=1.[NH2:24][C@H:25]([C:29]([OH:31])=O)[CH:26]([CH3:28])[CH3:27].[NH2:32][C@H:33]([C:41]([OH:43])=O)[CH2:34][C:35]1[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=1>>[NH2:11][C@H:12]([C:21]([NH:32][C@H:33]([C:41]([NH:24][C@H:25]([C:29]([NH:11][C@H:12]([C:21]([NH:1][C@H:2]([C:8]([OH:10])=[O:9])[CH2:3][CH2:4][CH2:5][CH2:6][NH2:7])=[O:23])[CH2:13][C:14]1[CH:15]=[CH:16][C:17]([OH:20])=[CH:18][CH:19]=1)=[O:31])[CH:26]([CH3:28])[CH3:27])=[O:43])[CH2:34][C:35]1[CH:36]=[CH:37][CH:38]=[CH:39][CH:40]=1)=[O:23])[CH2:13][C:14]1[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=1

Participants

Reactant 4

HCID 5962L-Lysine

HCID 6057L-Tyrosine

HCID 6140L-Phenylalanine

HCID 6287L-Valine

Product 1

HCID 11445447HCID 11445447, compound

Procedure

Lys, 1.06; Tyr, 0.92; Val, 1.01; Phe, 2.00; variance, 0.003; 0.25 Ci Mol-1 ; ε 280 nM, +3319°; M 578 nM ; RF : T3, 0.94; T4, 0.32; T2, 0.32; hplc, 1500 sec.; P, 0.14.

Workup

customε 280 nM, +3319°
customhplc, 1500 sec

Sources & evidence

ORD record: ord-069fb984038f4117b2533b8fd4169d76
Source dataset: uspto-grants-1984_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04455303

Reaction notes

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