Hydrochloric Acid → 6-(1-Hydroxy-2-piperazinylbutyl)-3,4-dihydrocarbostyril
Reaction equation
[O:1]=[C:2]([C:12]1[CH:13]=[C:14]2[C:19](=[CH:20][CH:21]=1)[NH:18][C:17](=[O:22])[CH2:16][CH2:15]2)[CH:3]([N:6]1[CH2:11][CH2:10][NH:9][CH2:8][CH2:7]1)[CH2:4][CH3:5].[BH4-].[Na+].Cl.[OH-].[Na+]>CO.O>[OH:1][CH:2]([C:12]1[CH:13]=[C:14]2[C:19](=[CH:20][CH:21]=1)[NH:18][C:17](=[O:22])[CH2:16][CH2:15]2)[CH:3]([N:6]1[CH2:11][CH2:10][NH:9][CH2:8][CH2:7]1)[CH2:4][CH3:5]Participants
Reactant 4
Product 1
Reagents, catalysts & solvents 2
Procedure
2.5 Grams of 6-(1-oxo-2-piperazinylbutyl)-3,4-dihydrocarbostyril was mixed in 80 ml of methanol and 1.6 g of sodium borohydride was added gradually under stirring at a room temperature in 15 minutes and further stirred at a room temperature for 2 hours. To the reaction mixture was added 5 ml of concentrated hydrochloric acid and the reaction mixture was concentrated under a reduced pressure to dryness. The residue thus obtained was dissolved by adding 10 ml of water and the pH of the solution was adjusted to 6-7 by adding 2N-sodium hydroxide aqueous solution at a room temperature and stirred to precipitate crystals. The crystals were collected by filtration washed with water and dried to obtain 1.2 g of 6-(1-hydroxy-2-piperazinylbutyl)-3,4-dihydrocarbostyril in colorless powder.
Workup
- stirringfurther stirred at a room temperature for 2 hours
- concentrationthe reaction mixture was concentrated under a reduced pressure to dryness
- customThe residue thus obtained
- dissolutionwas dissolved
- stirringstirred
- customto precipitate crystals
- filtrationThe crystals were collected by filtration
- washwashed with water
- customdried
Sources & evidence
- ORD record
- ord-66ac57c1e79e40a589189ed9c4c9176b
- Source dataset
- uspto-grants-1984_06
- Patent number
- US04455422
Reaction notes
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