反应详情

2.5 Grams of 6-{1-hydroxy-4-[bis-chloroethyl-amino]butyl}-3,4-dihydrocarbostyril, 1.5 g of aniline and 2.2 g of potassium carbonate were mixed in 150 ml of ethanol and the mixture was refluxed by heating for 24 hours. The reaction mixture was concentrated under a reduced pressure and the residue thus obtained was extracted with chloroform. The chloroform layer was washed with water, dried and chloroform was removed by distillation. The residue thus obtained was separated and purified by a preparative thin layer chromatography and recrystallized from isopropanol to obtain 0.2 g of 6-[1-hydroxy-4-(4-phenyl-1-piperazinyl)butyl]-3,4-dihydrocarbostyril in colorless needle-like crystals.

1. temperaturethe mixture was refluxed
2. temperatureby heating for 24 hours
3. concentrationThe reaction mixture was concentrated under a reduced pressure
4. customthe residue thus obtained
5. extractionwas extracted with chloroform
6. washThe chloroform layer was washed with water
7. customdried
8. customchloroform was removed by distillation
9. customThe residue thus obtained
10. customwas separated
11. custompurified by a preparative thin layer chromatography
12. customrecrystallized from isopropanol