HCID 54434083, compound → Hydrocarbostyril

HRID 1263138Notes

Reaction equation

HRID 1263138 reaction equation
CC1C=CC(N2CCN(CCC=C[C:18]3[CH:19]=[C:20]4[C:25](=[CH:26][CH:27]=3)[NH:24][C:23](=[O:28])[CH2:22][CH2:21]4)CC2)=CC=1>O1CCOCC1.[Pd]>[NH:24]1[C:25]2[C:20](=[CH:19][CH:18]=[CH:27][CH:26]=2)[CH2:21][CH2:22][C:23]1=[O:28]

Participants

4

Reactant 1

HCID 54434083HCID 54434083, compound

Product 1

HCID 64796Hydrocarbostyril

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 312751,4-DioxaneSolvent

Procedure

1.0 Gram of 6-{4-[4-(4-Methylphenyl)-1-piperazinyl]-1-butenyl}-3,4-dihydrocarbostyril and 0.2 g of palladium black were suspended in 100 ml of dioxane and the mixture was catalytically hydrogenated under an ordinary pressure at an ordinary temperature. The catalyst was removed by filtration and the filtrate was dried under a reduced pressure. The residue was recrystallized from isopropanol-diisopropyl ether to obtain 6-{4-[4-methylphenyl)piperazinyl]-butyl}-3,4-dihydrocarbostyril in colorless prism-like crystals. Yield: 0.7 g. Melting point: 160°-161° C.

Workup

  1. customThe catalyst was removed by filtration
  2. customthe filtrate was dried under a reduced pressure
  3. customThe residue was recrystallized from isopropanol-diisopropyl ether

Sources & evidence

ORD record
ord-2fbd546a4afe4b068760c9effe52c026
Source dataset
uspto-grants-1984_06
Patent number
US04455422

Reaction notes

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