反应详情

To 4.06 g (7.8 mmole) of 2-amino-6-trifluoromethylbenzyl alcohol in a pressure bottle was added 60 ml of concentrated hydrochloric acid, the bottled stoppered and immersed in an oil bath maintained at 100°. The mixture was stirred for 1.5 hr., cooled and the precipitate filtered under suction. The colorless solid was washed with water and dried under high vacuum, yielding 3.28 g (75% yield) of a colorless solid; mp 155°-161°. The sample was used as such without further purification.

1. customimmersed in an oil bath
2. temperaturemaintained at 100°
3. temperature, cooled
4. filtrationthe precipitate filtered under suction
5. washThe colorless solid was washed with water
6. customdried under high vacuum