Hydrochloric Acid → 2-Amino-6-trifluoromethylbenzyl chloride

HRID 1263162Notes

Reaction equation

HRID 1263162 reaction equation
[NH2:1][C:2]1[CH:9]=[CH:8][CH:7]=[C:6]([C:10]([F:13])([F:12])[F:11])[C:3]=1[CH2:4]O.[ClH:14]>>[NH2:1][C:2]1[CH:9]=[CH:8][CH:7]=[C:6]([C:10]([F:13])([F:12])[F:11])[C:3]=1[CH2:4][Cl:14]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 54486842HCID 54486842, compound

Product 1

HCID 204548212-Amino-6-trifluoromethylbenzyl chlorideYield 75%

Procedure

To 4.06 g (7.8 mmole) of 2-amino-6-trifluoromethylbenzyl alcohol in a pressure bottle was added 60 ml of concentrated hydrochloric acid, the bottled stoppered and immersed in an oil bath maintained at 100°. The mixture was stirred for 1.5 hr., cooled and the precipitate filtered under suction. The colorless solid was washed with water and dried under high vacuum, yielding 3.28 g (75% yield) of a colorless solid; mp 155°-161°. The sample was used as such without further purification.

Workup

  1. customimmersed in an oil bath
  2. temperaturemaintained at 100°
  3. temperature, cooled
  4. filtrationthe precipitate filtered under suction
  5. washThe colorless solid was washed with water
  6. customdried under high vacuum

Sources & evidence

ORD record
ord-60e0efe7ac2948af85ab7841257830d6
Source dataset
uspto-grants-1984_06
Patent number
USRE031617

Reaction notes

Loading…