反应详情

The product from Example 1 (10.6 g), 2,3-dihydroxy butane (8.5 g) and p-toluene sulfonic acid (1.5 g) in 200 ml benzene were refluxed to 2 hours, removing water with a Dean Stark trap. The solution wash washed with 10% NaOH, dried (MgSO4) and stripped. The product was chromatographed on a silica gel column, eluting with 30% ethyl ether:hexane. Yield: 3.8 g of the title product, mp 55°-57° C.

1. customremoving water with a Dean Stark trap
2. washThe solution wash
3. washwashed with 10% NaOH
4. dry with materialdried (MgSO4)
5. customThe product was chromatographed on a silica gel column
6. washeluting with 30% ethyl ether