HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → Piperazine, 1-(3-fluoro-2-pyridinyl)-, hydrochloride (1:2)
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sulfur Dioxide | HCID 1119 | — |
| Reactant | 1-(3-Fluoro-1-oxido-2-pyridinyl)piperazine | HCID 70481608 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | Piperazine, 1-(3-fluoro-2-pyridinyl)-, hydrochloride (1:2) | HCID 20455072 | — |
Reaction Steps
A solution of 3-fluoro-2-piperazinylpyridine N-oxide (2 mmol) in 10 ml of glacial acetic acid is warmed to about 85° C. saturated with anhydrous hydrogen chloride gas and treated with a fine stream of sulfur dioxide for 1 hour. The acetic acid is removed under reduced pressure and the residue is crystallized from an ethanol-ethyl acetate mixture to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04456604 |
| Source dataset | uspto-grants-1984_06 |
| ORD ID | ord-81243050073c44e3ad431e31170bdb4d |
| Source note | uspto-grants-1984_06 |