反应详情

To 100 ml of a tetrahydrofuran solution containing 1 g of ammonia, 9.5 g of the compound obtained in step (d) above was added dropwise at 0° to 5° C., and the mixture was stirred at room temperature for 30 minutes. The liquid reaction mixture was extracted with n-hexane, and the extract was washed with water and dried. The solvent was removed by distillation and the obtained oily substance was purified by column chromatography using silica gel to obtain 5.6 g of the intended compound in the form of an oil.

1. additionabove was added dropwise at 0° to 5° C.
2. customThe liquid reaction mixture
3. extractionwas extracted with n-hexane
4. washthe extract was washed with water
5. customdried
6. customThe solvent was removed by distillation
7. customthe obtained oily substance was purified by column chromatography