反应详情

A solution of 336 mg. of isopropyl 5-benzoyl-7-bromo-1,2-dihydro-3H-pyrrolo[1,2-a]-pyrrole-1-carboxylate in 10 ml. of methanol is treated with a solution of 690 mg. of potassium carbonate in 5 ml. of water. The reaction mixture is refluxed under nitrogen atmosphere for 30 minitres, cooled, and evaporated to dryness. The residue is taken up in 10 ml. of 10% aqueous hydrochloric acid and 50 ml. of water and the resultant mixture extracted with ethyl acetate (2×50 ml.). The combined extracts are dried over magnesium sulfate and evaporated to dryness under reduced pressure. Crystallization of the residue from ethyl acetate-hexane affords 5-benzoyl-7-bromo-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid.

1. temperatureThe reaction mixture is refluxed under nitrogen atmosphere for 30 minitres
2. temperaturecooled
3. customevaporated to dryness
4. extractionof water and the resultant mixture extracted with ethyl acetate (2×50 ml.)
5. dry with materialThe combined extracts are dried over magnesium sulfate
6. customevaporated to dryness under reduced pressure
7. customCrystallization of the residue from ethyl acetate-hexane