Triethylamine → HCID 20159912, compound

HRID 1263338Notes

Reaction equation

HRID 1263338 reaction equation
[C:1]([NH:4][CH:5]([CH3:8])[CH2:6][NH2:7])(=[O:3])[CH3:2].C(N(CC)CC)C.[CH:16]1[C:25]2[CH:24]=[CH:23][CH:22]=[C:21]([S:26](Cl)(=[O:28])=[O:27])[C:20]=2[CH:19]=[CH:18][N:17]=1>C(Cl)(Cl)Cl>[C:1]([NH:4][CH:5]([CH3:8])[CH2:6][NH:7][S:26]([C:21]1[C:20]2[CH:19]=[CH:18][N:17]=[CH:16][C:25]=2[CH:24]=[CH:23][CH:22]=1)(=[O:27])=[O:28])(=[O:3])[CH3:2]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 33716555-Isoquinolinesulfonyl chlorideHCID 23499646N-(2-Amino-1-methylethyl)acetamide

Product 1

HCID 20159912HCID 20159912, compoundYield 83%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent2×

Procedure

In 50 ml of chloroform were dissolved 2.0 g of 2-acetamidopropylamine and 2.6 g of triethylamine, and to the solution was added dropwise 50 ml of a chloroform solution containing 3.28 g of 5-isoquinolinesulfonyl chloride under cooling with ice. Then the mixed solution was stirred at a temperature of 15° C. to 25° C. for two hours, and the reaction solution was washed with water, dried with anhydrous magnesium sulfate and the chloroform was distilled therefrom under reduced pressure to give 3.67 g of N-(2-acetamidopropyl)-5-isoquinolinesulfonamide in a yield of 83%.

Workup

  1. temperatureunder cooling with ice
  2. washthe reaction solution was washed with water
  3. dry with materialdried with anhydrous magnesium sulfate
  4. distillationthe chloroform was distilled

Sources & evidence

ORD record
ord-7cd92b319e2e4cb681db2c396e42a3df
Source dataset
uspto-grants-1984_06
Patent number
US04456757

Reaction notes

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