HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 4-Fluoro-3-nitrobenzaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 4-Chloro-3-nitrobenzaldehyde | HCID 85505 | — |
| Reactant | Potassium Fluoride | HCID 522689 | — |
| Solvent | Sulfolane | HCID 31347 | — |
| Product | 4-Fluoro-3-nitrobenzaldehyde | HCID 598129 | 92.5% |
Reaction Steps
18.6 g (0.1 mol) of 4-chloro-3-nitrobenzaldehyde and 8.7 g (0.15 mol) of potassium fluoride in 100 ml of sulpholane are stirred for 1 hour at 180° C. The mixture is stirred with 300 ml of water and the aldehyde is extracted with methylene chloride. After the customary working-up , 17.1 g of 92% strength 4-fluoro-3-nitrobenzaldehyde are obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04456772 |
| Source dataset | uspto-grants-1984_06 |
| ORD ID | ord-f071ae876cf041d5913356dd0bba083a |
| Source note | uspto-grants-1984_06 |