Phosphoric Acid → 4-methylbenzothiazole-5-carboxylic Acid

HRID 1263404Notes

Reaction equation

HRID 1263404 reaction equation
[CH3:1][C:2]1[C:7]2[N:8]=[CH:9][S:10][C:6]=2[CH:5]=[CH:4][C:3]=1[C:11]([O:13]C)=[O:12].P(=O)(O)(O)O>[OH-].[K+]>[CH3:1][C:2]1[C:7]2[N:8]=[CH:9][S:10][C:6]=2[CH:5]=[CH:4][C:3]=1[C:11]([OH:13])=[O:12]

Participants

4

Reactant 2

HCID 1004Phosphoric AcidHCID 18616057Methyl 4-Methylbenzothiazole-5-carboxylate

Product 1

HCID 114809704-methylbenzothiazole-5-carboxylic Acid

Reagents, catalysts & solvents 1

HCID 14797Potassium HydroxideSolvent

Procedure

16.6 g of methyl 4-methylbenzothiazole-5-carboxylate (0.08 mol) were dissolved in 280 ml of 5% strength aqueous potassium hydroxide solution and heated at reflux for 2.5 h. After cooling, the mixture was acidified using phosphoric acid. The product was filtered off and subsequently dried.

Workup

  1. temperatureheated
  2. temperatureat reflux for 2.5 h
  3. temperatureAfter cooling
  4. filtrationThe product was filtered off
  5. customsubsequently dried

Sources & evidence

ORD record
ord-9661301a5c1d4a79a1f6f2a60ed9e312
Source dataset
uspto-grants-2003_04
Patent number
US06541423B1

Reaction notes

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