5-(3,4-Dichlorobenzyl-carbamoyl)-thiophene-2-carboxylic acid → 5(3,4-Dichlorobenzylcarbamoyl)pyridine-2-carbonylchloride

HRID 1263614Notes

Reaction equation

HRID 1263614 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:18]=[CH:19][C:20]=1[Cl:21])[CH2:5][NH:6][C:7]([C:9]1[CH:10]=[CH:11][C:12]([C:15](O)=[O:16])=[N:13][CH:14]=1)=[O:8].[Cl:22]C1C=C(C=CC=1Cl)CNC(C1SC(C(O)=O)=CC=1)=O>>[Cl:1][C:2]1[CH:3]=[C:4]([CH:18]=[CH:19][C:20]=1[Cl:21])[CH2:5][NH:6][C:7]([C:9]1[CH:10]=[CH:11][C:12]([C:15]([Cl:22])=[O:16])=[N:13][CH:14]=1)=[O:8]

Participants

3

Reactant 2

HCID 186171155-(3,4-Dichlorobenzyl-carbamoyl)-thiophene-2-carboxylic acidHCID 186171845(3,4-Dichlorobenzylcarbamoyl)-pyridine-2-carboxylic acid

Product 1

HCID 186172055(3,4-Dichlorobenzylcarbamoyl)pyridine-2-carbonylchloride

Procedure

Compound (13(b)) was treated in an analogous manner to compound (12(b)) in Example 12 to give 5(3,4-dichlorobenzylcarbamoyl)pyridine-2-carbonylchloride (13(c)) which was used crude in the next reaction.

Sources & evidence

ORD record
ord-52baa47682b942eabd003fbf7fca1a71
Source dataset
uspto-grants-2003_04
Patent number
US06541491B1

Reaction notes

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