反应详情

To a solution of 3-(6-Amino-3H-isobenzofuran-1-ylidene)-1,3-dihydro-indol-2-one (50.0 mg, 0.189 mmol) and N,N-diisopropylethylamine (98.8 μL, 0.567 mmol) in 2.0 mL THF was added acetyl chloride (13.4 μL, 0.189 mmol). After stirring a troom temperature for 1 h, the slurry was partitioned between NaHCO3 solution and EtOAc (warmed to dissolve solid). The organic phase was washed with H2O, 4% aqueout HCl solution, H2O, saturated NaHCO3, brine and dried with Na2SO4. After concentrating in vacuo the residue was triturated with EtOAc to give the title compound (47.4 mg, 82%) as a yellow solid.

1. customthe slurry was partitioned between NaHCO3 solution and EtOAc (warmed to dissolve solid)
2. washThe organic phase was washed with H2O, 4% aqueout HCl solution, H2O, saturated NaHCO3, brine
3. dry with materialdried with Na2SO4
4. concentrationAfter concentrating in vacuo the residue
5. customwas triturated with EtOAc