反应详情

A mixture of 3-(5-Amino-3H-isobenzofuran-1-ylidene)-1,3-dihydro-indol-2-one (50.0 mg, 0.189 mmol), acetaldehyde (10.0 mg, 0.227 mmol), and sodium triacetoxyborohydride (52.1 mg, 0.246 mmol) was stirred at room temperature for 50.5 h. The reaction was then partitioned between EtOAc and H2O. The organic phase was washed with H2O, brine and then dried with Na2SO4. The solvent was removed in vacuo and the solid chromatographed (CHCl3/MeOH, 97.5:2.5) to afford the title compound (14.1 mg, 25%) as a yellow solid.

1. customThe reaction was then partitioned between EtOAc and H2O
2. washThe organic phase was washed with H2O, brine
3. dry with materialdried with Na2SO4
4. customThe solvent was removed in vacuo
5. customthe solid chromatographed (CHCl3/MeOH, 97.5:2.5)