Ethyl pyruvate → N-(3,4Difluorophenyl)alanine Ethyl Ester

HRID 1263851Notes

Reaction equation

HRID 1263851 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:6]=[CH:7][C:8]=1[F:9])[NH2:5].[C:10]([O:15][CH2:16][CH3:17])(=[O:14])[C:11]([CH3:13])=O>>[CH2:16]([O:15][C:10](=[O:14])[C@H:11]([CH3:13])[NH:5][C:4]1[CH:6]=[CH:7][C:8]([F:9])=[C:2]([F:1])[CH:3]=1)[CH3:17]

Participants

3

Reactant 2

HCID 12041Ethyl pyruvateHCID 774693,4-Difluoroaniline

Product 1

HCID 15434838N-(3,4Difluorophenyl)alanine Ethyl Ester

Procedure

Following General Procedure AA above and using 3,4-difluoroaniline (Aldrich) and ethyl pyruvate (Aldrich), the title compound was prepared. The reaction was monitored by tlc on silica gel (Rf=0.4 in 25% EtOAc/hexanes) and purification was by preparative plate chromatography (silica gel using 25% EtOAc/hexanes as the eluant).

Workup

  1. customThe reaction was monitored by tlc on silica gel (Rf=0.4 in 25% EtOAc/hexanes) and purification

Sources & evidence

ORD record
ord-fd97f5410ec94a80902b2443c1d2fa7e
Source dataset
uspto-grants-2003_04
Patent number
US06541466B2

Reaction notes

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