(3-Bromophenyl)acetic acid → 2-[(3-bromophenyl)acetamido]butyric Acid isobutyl Ester

HRID 1263916Notes

Reaction equation

HRID 1263916 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([CH2:8][C:9]([OH:11])=O)[CH:5]=[CH:6][CH:7]=1.[NH2:12][CH:13]([CH2:21][CH3:22])[C:14]([O:16][CH2:17][CH:18]([CH3:20])[CH3:19])=[O:15]>>[CH2:17]([O:16][C:14](=[O:15])[CH:13]([NH:12][C:9](=[O:11])[CH2:8][C:4]1[CH:5]=[CH:6][CH:7]=[C:2]([Br:1])[CH:3]=1)[CH2:21][CH3:22])[CH:18]([CH3:19])[CH3:20]

Participants

3

Reactant 2

HCID 74653(3-Bromophenyl)acetic acidHCID 13743360Isobutyl 2-aminobutyrate

Product 1

HCID 154817712-[(3-bromophenyl)acetamido]butyric Acid isobutyl Ester

Procedure

Following General Procedure BI above and using 3-bromophenylacetic acid (Aldrich) and iso-butyl 2-aminobutyrate (prepared following General Procedure BJ above), the title compound was prepared. The reaction was monitored by tlc on silica gel and purification was by filtration as described in the general procedure.

Workup

  1. customThe reaction was monitored by tlc on silica gel and purification
  2. filtrationwas by filtration

Sources & evidence

ORD record
ord-a424dadbaee14144b38c8ec2f717d05f
Source dataset
uspto-grants-2003_04
Patent number
US06541466B2

Reaction notes

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