HRID1264072

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：COC(=O)c1ccc(CNc2ccc(O[Si](C)(C)C(C)(C)C)cc2NC(=O)c2ccc(OCCN3CCCC3)cc2)cc1OC

HCID12052636

未命名化合物

PRODUCTS

生成物

结构：COC(=O)c1ccc(Cn2c(-c3ccc(OCCN4CCCC4)cc3)nc3cc(O[Si](C)(C)C(C)(C)C)ccc32)cc1OC

HCID12052622

未命名化合物

收率 82%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID7237

o-Xylene

C8H10

PROCEDURE

实验过程

To the above amide (Example 1, Part E; 3.95, 6.23 mmol) was added o-xylene (50 mL) and the mixture heated at reflux overnight. After concentrating under reduced pressure the resulting residue was purified by flash chromatography (SiO2, 5% MeOH in CHCl3 with 1% Et3N v/v added); yielding 3.1 g (82%) of the desired product.

WORKUP

后处理

temperaturethe mixture heated
temperatureat reflux overnight
concentrationAfter concentrating under reduced pressure the resulting residue
customwas purified by flash chromatography (SiO2, 5% MeOH in CHCl3 with 1% Et3N
additionv/v added)

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-17e0be0bfea84aa6b601d2c6ed6230a1
来源数据集: uspto-grants-2003_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06541499B1
来源说明: uspto-grants-2003_04

反应 SMILES

[Si:1]([O:8][C:9]1[CH:14]=[CH:13][C:12]([NH:15][CH2:16][C:17]2[CH:26]=[CH:25][C:20]([C:21]([O:23][CH3:24])=[O:22])=[C:19]([O:27][CH3:28])[CH:18]=2)=[C:11]([NH:29][C:30](=O)[C:31]2[CH:36]=[CH:35][C:34]([O:37][CH2:38][CH2:39][N:40]3[CH2:44][CH2:43][CH2:42][CH2:41]3)=[CH:33][CH:32]=2)[CH:10]=1)([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2]>CC1C=CC=CC=1C>[Si:1]([O:8][C:9]1[CH:14]=[CH:13][C:12]2[N:15]([CH2:16][C:17]3[CH:26]=[CH:25][C:20]([C:21]([O:23][CH3:24])=[O:22])=[C:19]([O:27][CH3:28])[CH:18]=3)[C:30]([C:31]3[CH:36]=[CH:35][C:34]([O:37][CH2:38][CH2:39][N:40]4[CH2:41][CH2:42][CH2:43][CH2:44]4)=[CH:33][CH:32]=3)=[N:29][C:11]=2[CH:10]=1)([C:4]([CH3:6])([CH3:5])[CH3:7])([CH3:2])[CH3:3]