反应详情

To a stirred, partial solution of 4-[4-(4-methyl-benzoylamino)-phenyl]-4-oxo-butyric acid, methyl ester (0.5748 g, 0.00177 mol) in THF (11 mL) was added 1.0 M NaOH (3.7 mL, 0.0037 mol), and the mixture was stirred overnight. The resulting suspension was filtered, and the filtercake was washed with THF. The solids were partitioned between EtOAc-THF and 0.2 M HCl, and left for 8 days. The solids were filtered, washed with water, and dried in vacuo to give 0.2133 g of 4-[4-(4-methyl-benzoylamino)-phenyl]-4-oxo-butyric acid as an off-white solid; mp 257-258° C.

1. filtrationThe resulting suspension was filtered
2. washthe filtercake was washed with THF
3. customThe solids were partitioned between EtOAc-THF and 0.2 M HCl
4. waitleft for 8 days
5. filtrationThe solids were filtered
6. washwashed with water
7. customdried in vacuo