2-Fluorotoluene → N-methyl-3-(2-methylphenoxy)-3-phenylpropan-1-amine

HRID 1264193Notes

Reaction equation

HRID 1264193 reaction equation
[CH3:1][NH:2][CH2:3][CH2:4][CH:5]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)[OH:6].F[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=1[CH3:20]>CN1CCN(C)C1=O>[CH3:1][NH:2][CH2:3][CH2:4][CH:5]([O:6][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=1[CH3:20])[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1

Participants

4

Reactant 2

HCID 72412-FluorotolueneHCID 27339893-Methylamino-1-phenylpropanol

Product 1

HCID 6850813N-methyl-3-(2-methylphenoxy)-3-phenylpropan-1-amine

Reagents, catalysts & solvents 1

HCID 66611,3-Dimethyl-2-imidazolidinoneSolvent

Procedure

reacting an alkoxide of N-methyl-3-phenyl-3-hydroxypropylamine with 2-fluorotoluene in 1,3-dimethyl-2-imidazolidinone to give N-methyl-3-(2-methylphenoxy)-3-phenylpropylamine;

Sources & evidence

ORD record
ord-4c981e30660241a59c3e1878c027c9d0
Source dataset
uspto-grants-2003_04
Patent number
US06541668B1

Reaction notes

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