2-Fluorotoluene → N,N-Dimethyl-3-phenyl-3-(o-tolyloxy)propan-1-amine

HRID 1264194Notes

Reaction equation

HRID 1264194 reaction equation
[CH3:1][N:2]([CH2:4][CH2:5][CH:6]([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[OH:7])[CH3:3].F[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=1[CH3:21]>CN1CCN(C)C1=O>[CH3:1][N:2]([CH2:4][CH2:5][CH:6]([O:7][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=1[CH3:21])[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[CH3:3]

Participants

4

Reactant 2

HCID 72412-FluorotolueneHCID 1106653-(Dimethylamino)-1-phenylpropan-1-ol

Product 1

HCID 12807420N,N-Dimethyl-3-phenyl-3-(o-tolyloxy)propan-1-amine

Reagents, catalysts & solvents 1

HCID 66611,3-Dimethyl-2-imidazolidinoneSolvent

Procedure

reacting an alkoxide of N,N-dimethyl-3-phenyl-3-hydroxypropylamine) with 2-fluorotoluene in 1,3-dimethyl-2-imidazolidinone to give N,N-dimethyl-3-(2-methylphenoxy)-3-phenylpropylamine;

Sources & evidence

ORD record
ord-a1a1d6d3f50745cfbd88da0d427641f2
Source dataset
uspto-grants-2003_04
Patent number
US06541668B1

Reaction notes

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