N-Methyltaurine → 2-[(4-{4-[2-(3-Cyano-1H-indol-5-yl)-ethylcarbamoyl]-phenyl}-pyrimidin-2-yl)-methyl-amino]-ethanesulfonic acid

HRID 1264252Notes

Reaction equation

HRID 1264252 reaction equation
[CH3:1][NH:2][CH2:3][CH2:4][S:5]([OH:8])(=[O:7])=[O:6].[C:9]([C:11]1[C:19]2[C:14](=[CH:15][CH:16]=[C:17]([CH2:20][CH2:21][NH:22][C:23](=[O:37])[C:24]3[CH:29]=[CH:28][C:27]([C:30]4[CH:35]=[CH:34][N:33]=[C:32](Cl)[N:31]=4)=[CH:26][CH:25]=3)[CH:18]=2)[NH:13][CH:12]=1)#[N:10]>>[C:9]([C:11]1[C:19]2[C:14](=[CH:15][CH:16]=[C:17]([CH2:20][CH2:21][NH:22][C:23]([C:24]3[CH:29]=[CH:28][C:27]([C:30]4[CH:35]=[CH:34][N:33]=[C:32]([N:2]([CH3:1])[CH2:3][CH2:4][S:5]([OH:8])(=[O:7])=[O:6])[N:31]=4)=[CH:26][CH:25]=3)=[O:37])[CH:18]=2)[NH:13][CH:12]=1)#[N:10]

Participants

3

Reactant 2

HCID 7882N-MethyltaurineHCID 18617562N-[2-(3-Cyano-1H-indol-5-yl)-ethyl]-4-[2-chloropyrimidin-4-yl]benzamide

Product 1

HCID 544473622-[(4-{4-[2-(3-Cyano-1H-indol-5-yl)-ethylcarbamoyl]-phenyl}-pyrimidin-2-yl)-methyl-amino]-ethanesulfonic acid

Procedure

Using 2-methylamino-ethyl sulphonic acid and N-[2-(3-Cyano-1H-indol-5-yl)-ethyl]-4-[2-chloro-pyrimidin-4-yl]-benzamide (reference example 1az) as substrates.

Sources & evidence

ORD record
ord-511cdd9458b94501a8b4f92053fe56ca
Source dataset
uspto-grants-2003_04
Patent number
US06541505B1

Reaction notes

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