5-(Dimethylamino)amylamine → N-[2-(3-Cyano-1H-indol-5-yl)-ethyl]-4-[2-(5-dimethylamino-pentylamino)-pyrimidin-4-yl]-benzamide

HRID 1264264Notes

Reaction equation

HRID 1264264 reaction equation
[CH3:1][N:2]([CH3:9])[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][NH2:8].[C:10]([C:12]1[C:20]2[C:15](=[CH:16][CH:17]=[C:18]([CH2:21][CH2:22][NH:23][C:24](=[O:38])[C:25]3[CH:30]=[CH:29][C:28]([C:31]4[CH:36]=[CH:35][N:34]=[C:33](Cl)[N:32]=4)=[CH:27][CH:26]=3)[CH:19]=2)[NH:14][CH:13]=1)#[N:11]>>[C:10]([C:12]1[C:20]2[C:15](=[CH:16][CH:17]=[C:18]([CH2:21][CH2:22][NH:23][C:24](=[O:38])[C:25]3[CH:30]=[CH:29][C:28]([C:31]4[CH:36]=[CH:35][N:34]=[C:33]([NH:8][CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][N:2]([CH3:9])[CH3:1])[N:32]=4)=[CH:27][CH:26]=3)[CH:19]=2)[NH:14][CH:13]=1)#[N:11]

Participants

3

Reactant 2

HCID 34659255-(Dimethylamino)amylamineHCID 18617562N-[2-(3-Cyano-1H-indol-5-yl)-ethyl]-4-[2-chloropyrimidin-4-yl]benzamide

Product 1

HCID 18617761N-[2-(3-Cyano-1H-indol-5-yl)-ethyl]-4-[2-(5-dimethylamino-pentylamino)-pyrimidin-4-yl]-benzamide

Procedure

Using 5-dimethylamino-pentylamine (reference example 93a) and and N-[2-(3-Cyano-1H-indol-5-yl)-ethyl]-4-[2-chloro-pyrimidin-4-yl]-benzamide (reference example 1az) as substrates. MS (ion spray) m/z 496 (M+H)+.

Sources & evidence

ORD record
ord-7b45926f99244eadbdf8b83990cd807a
Source dataset
uspto-grants-2003_04
Patent number
US06541505B1

Reaction notes

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