2,2,2-Trifluoroethanol → HCID 53740450, compound

HRID 1264270Notes

Reaction equation

HRID 1264270 reaction equation
[CH2:1]([OH:6])[C:2]([F:5])([F:4])[F:3].[C:7]([C:9]1[C:17]2[C:12](=[CH:13][CH:14]=[C:15]([CH2:18][CH2:19][NH:20][C:21](=[O:35])[C:22]3[CH:27]=[CH:26][C:25]([C:28]4[CH:33]=[CH:32][N:31]=[C:30](Cl)[N:29]=4)=[CH:24][CH:23]=3)[CH:16]=2)[NH:11][CH:10]=1)#[N:8]>>[C:7]([C:9]1[C:17]2[C:12](=[CH:13][CH:14]=[C:15]([CH2:18][CH2:19][NH:20][C:21](=[O:35])[C:22]3[CH:27]=[CH:26][C:25]([C:28]4[CH:33]=[CH:32][N:31]=[C:30]([O:6][CH2:1][C:2]([F:5])([F:4])[F:3])[N:29]=4)=[CH:24][CH:23]=3)[CH:16]=2)[NH:11][CH:10]=1)#[N:8]

Participants

3

Reactant 2

HCID 64092,2,2-TrifluoroethanolHCID 18617562N-[2-(3-Cyano-1H-indol-5-yl)-ethyl]-4-[2-chloropyrimidin-4-yl]benzamide

Product 1

HCID 53740450HCID 53740450, compound

Procedure

Using trifluoroethanol and N-[2-(3-Cyano-1H-indol-5-yl)-ethyl]-4-[2-chloro-pyrimidin-4-yl]-benzamide (reference example 1az) as substrates. MS (ion spray) m/z 466 (M+H)+.

Sources & evidence

ORD record
ord-b0b71c57cb6a4b4a8414d7662042f11d
Source dataset
uspto-grants-2003_04
Patent number
US06541505B1

Reaction notes

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