3-Amino-1,2-propanediol → HCID 18617729, compound

HRID 1264289Notes

Reaction equation

HRID 1264289 reaction equation
[OH:1][CH:2]([CH2:5][OH:6])[CH2:3][NH2:4].[C:7]([C:9]1[C:17]2[C:12](=[CH:13][CH:14]=[C:15]([CH2:18][CH2:19][NH:20][C:21](=[O:35])[C:22]3[CH:27]=[CH:26][C:25]([C:28]4[CH:33]=[CH:32][N:31]=[C:30](Cl)[N:29]=4)=[CH:24][CH:23]=3)[CH:16]=2)[NH:11][CH:10]=1)#[N:8]>>[C:7]([C:9]1[C:17]2[C:12](=[CH:13][CH:14]=[C:15]([CH2:18][CH2:19][NH:20][C:21](=[O:35])[C:22]3[CH:27]=[CH:26][C:25]([C:28]4[CH:33]=[CH:32][N:31]=[C:30]([NH:4][CH2:3][CH:2]([OH:1])[CH2:5][OH:6])[N:29]=4)=[CH:24][CH:23]=3)[CH:16]=2)[NH:11][CH:10]=1)#[N:8]

Participants

3

Reactant 2

HCID 735613-Amino-1,2-propanediolHCID 18617562N-[2-(3-Cyano-1H-indol-5-yl)-ethyl]-4-[2-chloropyrimidin-4-yl]benzamide

Product 1

HCID 18617729HCID 18617729, compound

Procedure

Using 2,3-dihydroxy-propylamine and N-[2-(3-Cyano-1H-indol-5-yl)-ethyl]-4-[2-chloro-pyrimidin-4-yl]-benzamide (reference example 1az) as substrates. MS (ion spray) m/z 457 (M+H)+.

Sources & evidence

ORD record
ord-6c83a5a8441046f580d85162b06c2cbb
Source dataset
uspto-grants-2003_04
Patent number
US06541505B1

Reaction notes

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