Acetic Anhydride → HCID 18617583, compound

HRID 1264326Notes

Reaction equation

HRID 1264326 reaction equation
[NH2:1][CH:2]1[CH2:7][CH2:6][N:5]([C:8]2[CH:29]=[CH:28][C:11]([C:12]([NH:14][CH2:15][CH2:16][C:17]3[CH:18]=[C:19]4[C:23](=[CH:24][CH:25]=3)[NH:22][CH:21]=[C:20]4[C:26]#[N:27])=[O:13])=[CH:10][CH:9]=2)[CH2:4][CH2:3]1.[C:30](OC(=O)C)(=[O:32])[CH3:31]>N1C=CC=CC=1>[C:30]([NH:1][CH:2]1[CH2:3][CH2:4][N:5]([C:8]2[CH:9]=[CH:10][C:11]([C:12]([NH:14][CH2:15][CH2:16][C:17]3[CH:18]=[C:19]4[C:23](=[CH:24][CH:25]=3)[NH:22][CH:21]=[C:20]4[C:26]#[N:27])=[O:13])=[CH:28][CH:29]=2)[CH2:6][CH2:7]1)(=[O:32])[CH3:31]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 18617551HCID 18617551, compound

Product 1

HCID 18617583HCID 18617583, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

40 mg (0.09 mmol) of 4-(4-amino-piperidin-1-yl)-N-[2-(3-Cyano-1H-indol-5-yl)-ethyl]-benzamide. (reference Example 1aav). was dissolved in 2 ml of pyridine, 22 mg (0.22 mmol) of acetic anhydride was added and stirred at room temperature for 16 h. The reaction mixture was evaporated to dryness. MS (CI) 430 (M+H)+.

Workup

  1. customThe reaction mixture was evaporated to dryness

Sources & evidence

ORD record
ord-ecc14c0e40b54b2ba36f020d2fb46a28
Source dataset
uspto-grants-2003_04
Patent number
US06541505B1

Reaction notes

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