Phenol → 2-(2,2,2-Trifluoro-1-hydroxyethyl)phenol

HRID 1264336Notes

Reaction equation

HRID 1264336 reaction equation
[C:1]1([OH:7])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH:8](O)([OH:13])[C:9]([F:12])([F:11])[F:10]>>[F:10][C:9]([F:12])([F:11])[CH:8]([C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][C:1]=1[OH:7])[OH:13]

Participants

3

Reactant 2

HCID 996PhenolHCID 679012,2,2-Trifluoro-1,1-ethanediol

Product 1

HCID 28292952-(2,2,2-Trifluoro-1-hydroxyethyl)phenolYield 88%

Conditions

Temperature
100 °C

Procedure

9.3 g (100 mmol) of phenol and 3.9 g (25 mmol) of 75% fluoral hydrate are introduced into a 100 ml reactor. 5.0 g of hydrotalcite Mg6Al2(O4)16.4H2O are added. The mixture is heated at 100° C. for 5 hours. After treating the reaction medium according to the protocol described in Example 1, a yield of 88% of the corresponding alcohol is obtained with an ortho/para ratio equal to 1.

Workup

  1. additionAfter treating
  2. customthe reaction

Sources & evidence

ORD record
ord-8ccaaccc0b454352b7d312c0210d448e
Source dataset
uspto-grants-2003_04
Patent number
US06541674B2

Reaction notes

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