Phenol → 2-(2,2,2-Trifluoro-1-hydroxyethyl)phenol

Participants

Reaction Conditions

Reaction Steps

9.3 g (100 mmol) of phenol and 3.9 g (25 mmol) of 75% fluoral hydrate are introduced into a 100 ml reactor. 5.0 g of hydrotalcite Mg6Al2(O4)16.4H2O are added. The mixture is heated at 100° C. for 5 hours. After treating the reaction medium according to the protocol described in Example 1, a yield of 88% of the corresponding alcohol is obtained with an ortho/para ratio equal to 1.

Provenance & Evidence