HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1264337Generated: October 30, 2026
P-Cresol → 4-Methyl-2-(2,2,2-trifluoro-1-hydroxyethyl)phenol
https://huagongshe.com/reaction/1264337
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | P-Cresol | HCID 2879 | — |
| Reactant | 2,2,2-Trifluoro-1,1-ethanediol | HCID 67901 | — |
| Product | 4-Methyl-2-(2,2,2-trifluoro-1-hydroxyethyl)phenol | HCID 9815649 | 90% |
Reaction Steps
11.6 g (100 mmol) of p-cresol and 3.9 g (25 mmol) of 75% fluoral hydrate are introduced into a 100 ml reactor. 5.0 g of MgO are added. The mixture is heated at 100° C. for 6 hours. After treating according to the protocol described in Example 1, a yield of 90% of the expected alcohol is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06541674B2 |
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| Source dataset | uspto-grants-2003_04 |
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| ORD ID | ord-820d51df7627487dbe0ddb748cfda338 |
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| Source note | uspto-grants-2003_04 |
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