P-Cresol → 4-Methyl-2-(2,2,2-trifluoro-1-hydroxyethyl)phenol

HRID 1264337Notes

Reaction equation

HRID 1264337 reaction equation
[CH:1]1[C:6]([OH:7])=[CH:5][CH:4]=[C:3]([CH3:8])[CH:2]=1.[CH:9](O)([OH:14])[C:10]([F:13])([F:12])[F:11]>>[F:11][C:10]([F:13])([F:12])[CH:9]([C:1]1[CH:2]=[C:3]([CH3:8])[CH:4]=[CH:5][C:6]=1[OH:7])[OH:14]

Participants

3

Reactant 2

HCID 2879P-CresolHCID 679012,2,2-Trifluoro-1,1-ethanediol

Product 1

HCID 98156494-Methyl-2-(2,2,2-trifluoro-1-hydroxyethyl)phenolYield 90%

Conditions

Temperature
100 °C

Procedure

11.6 g (100 mmol) of p-cresol and 3.9 g (25 mmol) of 75% fluoral hydrate are introduced into a 100 ml reactor. 5.0 g of MgO are added. The mixture is heated at 100° C. for 6 hours. After treating according to the protocol described in Example 1, a yield of 90% of the expected alcohol is obtained.

Workup

  1. additionAfter treating

Sources & evidence

ORD record
ord-820d51df7627487dbe0ddb748cfda338
Source dataset
uspto-grants-2003_04
Patent number
US06541674B2

Reaction notes

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