HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → Hydrochloride methanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | N-Carbobenzoxysarcosine | HCID 97053 | — |
| Reactant | HCID 70002206 | HCID 70002206 | — |
| Solvent | Hexane | HCID 8058 | — |
| Product | Hydrochloride methanol | HCID 21893726 | — |
| Product | HCID 70002327 | HCID 70002327 | — |
Reaction Steps
Analogously, from Z-Sar-OH and methyl N-methyl was prepared 2-[[(Benzyloxycarbonyl-methyl-amino)-acetyl]-methyl-amino]-benzoic acid methyl ester as light yellow oil (Rf 0.3 hexane:EtOAc1:2), MS: 370 (M), which was deprotected according to 6.1. and transferred into its HCl.salt by treatment with HCl/MeOH to give 2-(Methyl-methylaminoacetyl-amino)-benzoic acid methyl ester·hydrochloride, MS: 237 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06541638B2 |
| Source dataset | uspto-grants-2003_04 |
| ORD ID | ord-8d296c45a83342de9bd2f15400d969a1 |
| Source note | uspto-grants-2003_04 |