Hydrochloric Acid → Hydrochloride methanol

HRID 1264383Notes

Reaction equation

HRID 1264383 reaction equation
N(C(OCC1C=CC=CC=1)=O)(C[C:4](O)=[O:5])C.[CH3:17][O:18][C:19](=[O:43])[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=1[N:26]([C:28](=[O:42])[CH2:29][N:30](C(OCC1C=CC=CC=1)=O)[CH3:31])[CH3:27].[ClH:44]>CCCCCC>[ClH:44].[CH3:4][OH:5].[CH3:17][O:18][C:19](=[O:43])[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=1[N:26]([CH3:27])[C:28](=[O:42])[CH2:29][NH:30][CH3:31].[ClH:44]

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 97053N-CarbobenzoxysarcosineHCID 70002206HCID 70002206, compound

Product 2

HCID 21893726Hydrochloride methanolHCID 70002327HCID 70002327, compound

Reagents, catalysts & solvents 1

HCID 8058HexaneSolvent

Procedure

Analogously, from Z-Sar-OH and methyl N-methyl was prepared 2-[[(Benzyloxycarbonyl-methyl-amino)-acetyl]-methyl-amino]-benzoic acid methyl ester as light yellow oil (Rf 0.3 hexane:EtOAc1:2), MS: 370 (M), which was deprotected according to 6.1. and transferred into its HCl.salt by treatment with HCl/MeOH to give 2-(Methyl-methylaminoacetyl-amino)-benzoic acid methyl ester·hydrochloride, MS: 237 (MH+).

Sources & evidence

ORD record
ord-8d296c45a83342de9bd2f15400d969a1
Source dataset
uspto-grants-2003_04
Patent number
US06541638B2

Reaction notes

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