N-(tert-butoxycarbonyl)glycine → HCID 70002012, compound

HRID 1264386Notes

Reaction equation

HRID 1264386 reaction equation
C([NH:8][CH2:9][C:10](O)=[O:11])(OC(C)(C)C)=O.[CH3:13][O:14][C:15](=[O:24])[C:16]1[CH:21]=[CH:20][C:19]([NH:22][CH3:23])=[CH:18][CH:17]=1>C(Cl)Cl.CO>[CH3:13][O:14][C:15](=[O:24])[C:16]1[CH:21]=[CH:20][C:19]([N:22]([C:10](=[O:11])[CH2:9][NH2:8])[CH3:23])=[CH:18][CH:17]=1

Participants

4

Reactant 2

HCID 78288N-(tert-butoxycarbonyl)glycineHCID 140375Methyl 4-methylaminobenzoate

Product 1

HCID 70002012HCID 70002012, compound

Reagents, catalysts & solvents 1

HCID 21226129Dichloromethane methanolSolvent

Procedure

BOC-glycine and methyl-4-methylaminobenzoate according to 1.2., followed by BOC-cleavage 3.1. to give 4-(Aminoacetyl-methyl-amino)-benzoic acid methyl ester as an orange gum (Rf 0.1 CH2Cl2:MeOH 9:1), MS: 222 (MH+).

Sources & evidence

ORD record
ord-3b3f0d43986a4d3fb7137156b9f5b2d5
Source dataset
uspto-grants-2003_04
Patent number
US06541638B2

Reaction notes

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