Phenethylamine → HCID 70001329, compound

HRID 1264388Notes

Reaction equation

HRID 1264388 reaction equation
[CH3:1][C:2]([O:5][C:6]([CH2:8][C@H:9]([N:13]([C:15](OCC1C=CC=CC=1)=O)C)[C:10](O)=[O:11])=[O:7])([CH3:4])[CH3:3].C1CC[CH:28]([NH:31]C2CCCCC2)CC1.[CH2:38](CN)[C:39]1[CH:44]=[CH:43][CH:42]=[CH:41][CH:40]=1.[ClH:47].CO>>[ClH:47].[C:2]([O:5][C:6](=[O:7])[CH2:8][C@H:9]([NH:13][CH3:15])[C:10]([N:31]([CH2:38][C:39]1[CH:40]=[CH:41][CH:42]=[CH:43][CH:44]=1)[CH3:28])=[O:11])([CH3:4])([CH3:3])[CH3:1]

Participants

4

Reactant 3

HCID 1001PhenethylamineHCID 21893726Hydrochloride methanolHCID 56777375HCID 56777375, compound

Product 1

HCID 70001329HCID 70001329, compound

Procedure

Z-N-Me-Asp(OtBu)—OH DCHA salt (1:1) and N-Benzylmethylamine according to 1.2., followed by deprotection (6.1.) and treatment with HCl/MeOH to give (S)-N-Benzyl-N-methyl-3-methylamino-succinamic acid tert-butyl ester-HCl, MS: 307 (MH+)

Sources & evidence

ORD record
ord-3e0163fb579842fa89088e2bffefb6ed
Source dataset
uspto-grants-2003_04
Patent number
US06541638B2

Reaction notes

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