4-Isopropylaniline → HCID 131723838, compound

HRID 1264389Notes

Reaction equation

HRID 1264389 reaction equation
[CH3:1][C:2]([O:5][C:6]([CH2:8][C@H:9]([N:13](C(OCC1C=CC=CC=1)=O)[CH3:14])[C:10](O)=[O:11])=[O:7])([CH3:4])[CH3:3].C1CCC(NC2CCCCC2)CC1.[CH:38]([C:41]1[CH:47]=[CH:46][C:44]([NH2:45])=[CH:43][CH:42]=1)([CH3:40])[CH3:39].[ClH:48].CO>>[ClH:48].[C:2]([O:5][C:6](=[O:7])[CH2:8][C@H:9]([NH:13][CH3:14])[C:10]([NH:45][C:44]1[CH:46]=[CH:47][C:41]([CH:38]([CH3:40])[CH3:39])=[CH:42][CH:43]=1)=[O:11])([CH3:3])([CH3:4])[CH3:1]

Participants

4

Reactant 3

HCID 74644-IsopropylanilineHCID 21893726Hydrochloride methanolHCID 56777375HCID 56777375, compound

Product 1

HCID 131723838HCID 131723838, compound

Procedure

Z-N-Me-Asp(OtBu)—OH DCHA salt (1:1) and 4-Isopropylaniline according to 1.2., followed by deprotection (6.1.) and treatment with HCl/MeOH to give (S)-N-(4-Isopropyl-phenyl)-3-methylamino-succinamic acid tert-butyl ester-HCl, MS: 321 (MH+).

Sources & evidence

ORD record
ord-05e08af7afa043ddba54cf137a794889
Source dataset
uspto-grants-2003_04
Patent number
US06541638B2

Reaction notes

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